Pathogenic Species and Genotypes of Bacterial Diversity in Relation to the Severity of Dental Caries

N/ACompletedNCT02056262

Centre Hospitalier Universitaire de Nīmes56 enrolled

Overview

The primary objective of this study is to estimate the distribution of pathogenic species and genotypes of bacterial diversity in 7 stages ICDAS (International Caries Detection and Assessment System) corresponding to the severity of dental caries among patients aged 3-45 years consulting in the Dentistry Departments of the Nîmes University Hospital and the Montpellier University Hospital.

Secondary objectives include: * Compare the distribution of bacterial species in relation to stages of severity of caries * Compare the results from plaque with those of saliva samples.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Dental Cavity

Interventions

Dental cavity evaluationOTHER

The dental cavities present will be evaluated using the ICDAS (International Caries Detection and Assessment System).

Saliva samplingBIOLOGICAL

A saliva sample will be harvested.

Plaque samplingBIOLOGICAL

Plaque samples from a healthy tooth and a tooth with a cavity will be harvested.

Eligibility

Sex: ALLMin age: 3 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Volunteers aged 3 to 45 who come in to the hospital for a dental consultation * Minors must have parental permission * The patient must have given his/her informed and signed consent Exclusion Criteria: * The patient is participating in another study * The patient is in an exclusion period determined by a previous study * The patient is pregnant, or breastfeeding * The patient has been on antibiotics within the past two months * Smokers * Teeth under current care * Parodontopathy * Use of a mouthwash within the last week * Insufficient numbers of healthy and/or teeth with carious lesions for carrying out the study

Locations (3)

CHRU de Montpellier - Centre de Soins, d'Enseignement et de Recherche Dentaires

Montpellier, France

CHRU de Montpellier - Hôpital La Colombière

Montpellier, France

CHRU de Nîmes - Hôpital Universitaire Carémeau

Nîmes, France

Outcomes

Primary Outcomes

Bacterial profile

Bacterial profiles will be constructed using saliva and plaque samples.

Time frame: Baseline (day 0)

ICDAS assessment

Dental caries will be assessed using the ICDAS (International Caries Detection and Assessment System) system

Time frame: Baseline (day 0)

Secondary Outcomes

Studies were stopped during high school? yes/no

Time frame: baseline (Day 0)

Does the patient have at least five fillings? yes/no

Time frame: Baseline (day 0)

Does the patient have at least one filling and one missing tooth on the anterior sector following the carious lesion? yes/no

Time frame: baseline (day 0)

Within the last 12 months, the patient has had dental care or tooth removal following the carious lesion? yes/no

Time frame: baseline (day 0)

Yesterday, did the patient eat at least three snacks (or sugary or carbonated drinks) between meals? yes/no

Time frame: Baseline (day 0)

Yesterday, did the patient brush his/her teeth fewer than 2 times? yes/no

Time frame: baseline (day 0)

The patient has at least one carious lesion restricted to the enamel? yes/no

Time frame: baseline (day 0)

The patient has at least one carious lesion restricted to the enamel on an anterior tooth or involving the smooth surface on a posterior tooth (yes/no)

Data from ClinicalTrials.gov

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