Multicentre LOGIC-Insulin Algorithm-guided Versus Nurse-directed Blood Glucose Control During Critical Illness (LOGIC-2)

Proportion of Patients With Severe Hypoglycaemia (<40 mg/dL) during the Intervention

Proportion of patients to have had one or more episodes of severe hypoglycaemia (\<40 mg/dL) during the intervention

Time frame: up to 14 days post-randomization

Incidence of Severe Hypoglycemia (<40 mg/dL) during the Intervention

Number of severe hypoglycaemic values as a fraction of all blood glucose measurements during the intervention

Time frame: up to 14 days post-randomization

Blood Glucose Level Per Treatment Group during the Intervention

Mean and median arterial blood glucose level

Time frame: up to 14 days post-randomization

Hyperglycaemic index (HGI)

Adequacy of reaching and maintaining the target range for blood glucose, as assessed by the Hyperglycaemic index (HGI)

Time frame: up to 14 days post-randomization

Time in target range

Time frame: up to 14 days post-randomization

Time to target range

Time frame: up to 14 days post-randomization

Daily maximal blood glucose difference

marker of blood glucose fluctuations

Time frame: up to 14 days post-randomization

Incidence of mild hypoglycaemia (blood glucose level < 70 mg/dL or 3.9 mmol/L) during the Intervention

Number of mild hypoglycaemic values as a fraction of all blood glucose measurements during the intervention

Time frame: up to 14 days post-randomization

Proportion of Patients With Mild Hypoglycaemia (blood glucose level < 70 mg/dL or 3.9 mmol/L) during the Intervention

Proportion of patients to have had one or more episodes of mild hypoglycaemia during the intervention

Time frame: up to 14 days post-randomization

Interval between blood glucose measurements

marker of workload

Time frame: up to 14 days post-randomization

Protocol compliance in the intervention group

the number and proportion of patients in which the LOGIC-Insulin was not followed for a time period of at least 8 hours, which is the duration of one nurse shift.

Time frame: up to 14 days post-randomization

Overrules in the intervention group

the number and proportions of recommendations by the software that were overruled by the bed-side nurses * Minor overrules: absolute insulin dose difference of \>0.1 and \< 1IU/h * Major overrules: absolute insulin dose difference of \>= 1IU/h * Major overrules will also be qualitatively assessed

Time frame: up to 14 days post-randomization

Incidence of new infections in the ICU

The diagnosis of "new infection" will be based on the administration of antibiotics, beyond the prophylactic scope

Time frame: up to 90 days post-randomization

Length of stay in the ICU

Time frame: up to 90 days post-randomization

Length of stay in the hospital

Time frame: up to 90 days post-randomization

Mortality in the ICU

Time frame: up to 90 days post-randomization

Mortality in the hospital

Time frame: up to 90 days post-randomization

Landmark 90-day mortality

Time frame: up to 90 days post-randomization

All direct medical costs from a healthcare payer's perspective

Time frame: up to 90 days post-randomization

Quality of Life

EuroQol-5D

Time frame: up to 90 days post-randomization