Hemodynamic Effects on Cerebral Autoregulation in Acute Stroke

N/ACompletedNCT02056821

Henry Ford Health System88 enrolled

Overview

This study investigates if there are hemodynamic alterations in acute stroke that predispose patients to impaired perfusion and regulation of cerebral blood flow. To test this, we will target recruitment of acute ischemic stroke patients who present to the ED within 12 hours of symptoms onset. Enrolled subjects will receive continuous noninvasive hemodynamic monitoring contemporaneous with measurements of cerebral blood flow velocities and cerebral oximetry.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Ischemic Stroke

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Suspected ischemic stroke within 12 hours of symptom onset * NIHSS ≥ 4 * Age 18 to 90 years Exclusion Criteria: * Baseline modified Rankin Scale \> 3 * Pregnancy * Intracranial hemorrhage on head CT * Mechanical ventilation prior to enrollment * Inadequate temporal windows for TCD analysis

Locations (1)

Henry Ford Hospital

Detroit, Michigan, United States

Outcomes

Primary Outcomes

Change in cerebral blood flow velocities

Cerebral flow velocities determined by bilateral MCA measurements by TCD

Time frame: initial 24 hours

Data from ClinicalTrials.gov

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