Scalp Nerve Block and Opioid Consumption in Brain Surgery

Phase 4CompletedNCT02057367

Chiang Mai University100 enrolled

Overview

Anterior scalp block with 0.5% plain Marcaine 20 ml. may reduce the intraoperative opioid consumption in neurosurgical patients who undergoing the supratentorial craniotomy compared to those who receive 0.9% normal saline solution (placebo).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

100

Conditions

Brain Tumour

Interventions

Scalp block with 0.5% plain MarcaineDRUG

Anterior scalp block will be done by using 0.5% plain Marcaine 20 ml.

Scalp block with 0.9% normal salineDRUG

Anterior scalp block will be done by using 0.9% normal saline 20 ml.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients who have supratentorial brain tumor 2. Patients have been scheduled to undergo an elective craniotomy to remove tumor in any surgical position 3. Patients have been general anesthetized with endotracheal intubation and control ventilation 4. Patients who have provided consent for the participation in the research and for the use of their medical record in research Exclusion Criteria: 1. Pregnant patients 2. Patients who have a history of local anesthetic allergy and/ or anaphylaxis

Locations (1)

Chiang Mai University

Chiang Mai, Chiang Mai, Thailand

Outcomes

Primary Outcomes

Intraoperative opioid consumption

The overall intravenous fentanyl consumption (microgram/ kilogram) during the surgery. The decision to administer fentanyl is guided by the changes of blood pressure and/ or heart rate greater than 20% from baseline level.

Time frame: During the supratentorial craniotomy surgery

Secondary Outcomes

systolic blood pressure change

The maximal systolic blood pressure within the first 5 minutes after skull pin insertion will be recorded. The systolic blood pressure change from baseline will be calculated. The unit is mmHg.

Time frame: within 5 minutes after skull pin insertion

Heart rate change

The maximal heart rate within the first 5 minutes after skull pin insertion will be recorded. The heart rate change from baseline level will be calculated. The unit is beats per minute.

Time frame: within 5 minutes after skull pin insertion

Data from ClinicalTrials.gov

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