The purpose of this study is to determine whether couples undergoing IVF/ICSI with male factor infertility, specifically with elevated sperm DNA damage, should testicular sperm extraction be utilized to improve their reproductive outcomes.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
25
Live birth rates
Time frame: Up to 1 year
sperm DNA damage
Time frame: Mesaured at baseline, 3 months and on the day of Intracytoplasmic sperm injection (ICSI) procedure
oocyte fertilization rates
Time frame: at approximately 18 hrs post Intracytoplasmic sperm injection (ICSI)
embryo cleavage rate
Time frame: Day 3 post oocytes retrieval
blastocyst rate
Time frame: Day 5 post oocytes retrieval
pregnancy rate
Clinical pregnancy was defined as the ultrasonographic visualization of one or more gestational sacs and fetal heart at the 6 to 8 week ultrasound
Time frame: 6 to 8 week ultrasound
rate of spontaneous abortion
Time frame: after a clinical pregnancy has been established, up to 10 months after procedure
birth defects
Time frame: 1-year following delivery
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