Immunogenicity and Safety of GlaxoSmithKline (GSK) Biologicals' Herpes Zoster Subunit (HZ/su) Vaccine in Adults 18 Years of Age or Older With Renal Transplant

Inclusion Criteria: * Subjects who, in the opinion of the investigator, can and will comply with the requirements of the protocol. * A male or female, aged 18 years or older and having reached the age of legal consent, on the date the informed consent is signed. * Written informed consent obtained from the subject. * Subject who has received an ABO compatible allogeneic renal transplant. * Subject receiving maintenance immunosuppressive therapy for the prevention of allograft rejection for a minimum of one month (30 days) prior to the first vaccination. * Subject without an episode of allograft rejection over the previous three months (90 days) prior to the first vaccination. * Subject with stable renal function, stability defined as: * less than 20% variability between last two creatinine measurements or calculated GFR * or in the opinion of the investigator after investigator review of more than the last two creatinine measurements or calculated GFRs. * Subject not less than 4 months (120 days) and not more than 18 months (547 days) after allograft transplantation at the time of the first vaccination. * Subjects with multiple dialysis options (peritoneal and/or more than one anatomical access site for haemodialysis) in the event acute or chronic dialysis is needed. * Female subjects of non-childbearing potential may be enrolled in the study. * Female subjects of childbearing potential may be enrolled in the study, if the subject: * has practiced adequate contraception for 30 days prior to vaccination, and * has a negative pregnancy test on the day of the first vaccination, and * has agreed to continue adequate contraception during the primary treatment period and for 2 months after completion of the vaccination series. Exclusion Criteria: * Any primary kidney disease with a high incidence of recurrent primary kidney disease. * Evidence of recurrent primary kidney disease within the current allograft. * Previous allograft loss secondary to recurrent primary kidney disease. * Multiple kidney transplants are allowed if the reason for a previous allograft's loss is not recurrent primary kidney disease. * More than one organ transplanted (i.e. kidney-liver, double kidney or kidney-other organ(s) transplanted). * History of events that, in the opinion of the investigator, may put subject at increased risk for chronic allograft dysfunction (e.g. delayed graft function, peri-operative complications). * Histologic reports of chronic allograft injury (e.g. transplant glomerulopathy, arteriopathy, C4d deposition). * Evidence of significant proteinuria in the opinion of the investigator. * Panel reactive antibody score (PRA or cPRA) that is unknown at the time of transplant. * Any autoimmune or potential immune-mediated disease including primary kidney disease. * Use of anti-CD20 or other B-cell monoclonal antibody agents (e.g., rituximab) as induction, maintenance and/or therapeutic immunosuppressive therapy for the prevention of allograft rejection within 9 months (274 days) of first dose of study vaccine/placebo. * Use of any investigational or non-registered product other than the study vaccine within 30 days preceding the first dose of study vaccine/placebo, or planned use during the study period. * Concurrent or planned participation in another clinical study, at any time during the study period, which has exposed or will expose the subject to an investigational or a non-registered product * Administration or planned administration of a live vaccine within 30 days prior to the first dose of study vaccine and ending 30 days after the last dose of study vaccine, or, administration or planned administration of a non-replicating vaccine within 8 days prior to or within 14 days after either dose of study vaccine. * Planned administration during the study of a varicella or HZ vaccine other than the study vaccine. * Previous vaccination against HZ or varicella within the 12 months preceding the first dose of study vaccine/placebo. * Occurrence of varicella or HZ per clinical history, within the 12 months preceding the first dose of study vaccine/placebo. * Failure to fully complete the 7-day pre-vaccination diary card distributed at the Pre-vaccination visit. * Evidence or high suspicion, in the opinion of the investigator, of noncompliance or nonadherence to use of induction and/or maintenance immunosuppressive therapies. * Any confirmed or suspected HIV, primary immunodeficiency disease, disseminated or untreated malignancy, or systemic infection. * History of any reaction or hypersensitivity likely to be exacerbated by any component of the vaccine or study material and equipment. * Any condition which, in the judgment of the investigator, would make intramuscular injection unsafe. * Any other condition that, in the opinion of the investigator, might interfere with the evaluations required by the study. * Acute disease and/or fever at the time of vaccination. * Fever is defined as temperature ≥ 37.5°C /99.5°F by oral route. The preferred route for recording temperature in this study will be oral. * Subjects with a minor illness (such as mild diarrhoea, mild upper respiratory infection) without fever may be enrolled at the discretion of the investigator. * Pregnant or lactating female. * Female planning to become pregnant or planning to discontinue contraceptive precautions (if of childbearing potential) before Month 3.