The Mechanisms of Diameter Changes in Retinal Vessels During Hypoxia

N/ACompletedNCT02059018

University of Aarhus20 enrolled

Overview

The primary objective is to study if a stimulation of nitric oxide and/or prostaglandin affect the diameter changes of retinal vessels during hypoxia. Diameter changes are studied using the Dynamic Vessel Analyzer.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Retinal Hypoxia

Interventions

COX-inhibitorDRUG

Administration of 1 drop voltaren 45 minutes before recordings of diameter changes of retinal vessels are initiated

NitroglycerinDRUG

Oral administration of tablet nitroglycerin 0,5mg 5 minutes before recordings of diameter changes of retinal vessels are initiated

COX-inhibitor + NitroglycerinDRUG

Combination of COX-inhibitor and nitroglycerin interventions.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age between \>19 and \<61 years * No known systemic or ocular diseases Exclusion Criteria: * Cardio-vascular disease * Lung disease * Epilepsy * Previous ocular disease * Previous treatment with medications influencing the intraocular pressure or the metabolism of nitric oxide or prostaglandins * Daily intake of medicine except contraceptive pills * Pregnancy or breastfeeding * Known allergy against any of the drugs used in the interventions

Locations (1)

Department of Ophtalmology, Aarhus University Hospital

Aarhus, Denmark

Outcomes

Primary Outcomes

Diameter changes of retinal vessels

Comparing the differences of diameter changes occuring during each of interventions

Time frame: Examination day 1 and 2

Data from ClinicalTrials.gov

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