While there is a consensus to perform pulmonary vein isolation (PVI) as a cornerstone for paroxysmal and persistent atrial fibrillation (AF), different additional ablation approaches are used for substrate modification: linear lesions, ablation of complex fractionated atrial electrograms (CFAE) or a combination of both. The aim of this study is to determine whether there is a difference in terms of freedom from arrhythmia recurrence between PVI with CFAE ablation in combination or not with linear lesions in patients with persistent AF.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
90
pulmonary vein Isolation (PVI), CFAE for substrate modification and direct current cardioversion (DCC) if AF persists
PVI, CFAE ablation. If AF persists linear lesions (anterior and roof line), cardioversion if AF persists
Deutsches Herzzentrum München
Munich, Germany
Freedom from atrial arrhythmia
Documented freedom from atrial arrhythmia (AF or AT) recurrence
Time frame: 12 months
Procedural and safety data
Duration of procedure, ablation time, fluoroscopy time and complications
Time frame: 12 months
Number and result of reablation procedure
Number of redo procedures, results and type of recurrent arrhythmia
Time frame: 12 months
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