The purpose of this study is to determine the temporal relationship between motor fluctuations and non-motor fluctuations in persons with Parkinson's disease. Observational study case-only
Objectives 1. how many patients will experience motor or nonmotor fluctuation during follow-up period? 2. in how many patients, does motor fluctuation precede nonmotor fluctuation? 3. in how many patients, does nonmotor fluctuation precede motor fluctuation? Participants: persons with Parkinson disease in early stage who does not have motor or nonmotor fluctuation Recruitment period: 3 years from the commencement of the study Follow-up period: 3 years for each participants
Study Type
OBSERVATIONAL
Enrollment
800
Seoul National University Hospital
Seoul, South Korea
RECRUITINGtime period from the onset of disease to the occurrence of motor or nonmotor fluctuation
The proportion of participants with motor and/or nonmotor fluctuation will be evaluated at 6, 12, 18, 24, 30, and 36 months after the enrollment of each participant in order to determine the time course of motor/nonmotor fluctuation in persons with early stage of Parkinson's disease.
Time frame: 6 months
sensitivity and specificity of self-diagnostic questionnaire of motor/nonmotor fluctuation
The participants will be checked regularly for the development of motor/nonmotor fluctuation during study period by both of self-diagnostic questionnaire and clinician. The validation of self-diagnostic questionnaire of motor/nonmotor fluctuation will be conducted compared to the clinician-evaluated occurrence of motor/nonmotor fluctuation.
Time frame: 3 years
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.