Effect of EGDT on Hepatic Perfusion in Patients With Septic Shock

N/AUnknownNCT02060773

Zhongda Hospital

Overview

To observe the effect of early goal directed therapy (EGDT) on hepatic perfusion in patients with septic shock. Hypothesis: Hepatic perfusion did not improved after EGDT in patients with septic shock.

Objective To observe the effect of early goal directed therapy (EGDT) on hepatic perfusion in patients with septic shock. Methods A prospective observational study was carried out. The eligible patients were treated with the standard procedure of EGDT. The hemodynamic data were recorded. Oxygen metabolism and hepatic function were monitored. Indocyanine clearance test was applied to detect the hepatic perfusion. Hemodynamics, hepatic perfusion, oxygen metabolism and hepatic function were compared before treatment, after EGDT and 24 hours after EGDT.

Study Type

OBSERVATIONAL

Conditions

Septic Shock

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. patients with septic shock 2. at least one of the EGDT criteria not achieved 3. informed consent accepted Exclusion Criteria: 1. ages below 18 or above 90 2. pregnancy 3. the time elapsed over 24 hours after onset of septic shock 4. chronic liver disease 5. terminal stage of disease 6. brain death 7. other types of shock 8. brain injury 9. allergic to iodine or indocyanine

Locations (1)

Affiliated Zhongda Hospital of Southeast University

Nanjing, Jiangsu, China

RECRUITING

Outcomes

Primary Outcomes

ICG-PDR and R15 before treatment, after EGDT and 24 hours after EGDT.

Time frame: 30 hours

Secondary Outcomes

28 days mortality

Follow up to determine the mortality in 28 days after inclusion

Time frame: 28 days

Central Contacts

Xiaohua Qiu, MD

CONTACT

0086-025-83262553 xiaohua0917@163.com

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.