Acute normovolemic hemodilution (ANH) is part of our current protocol to decrease post-operative bleeding and homologous blood transfusions post cardiopulmonary bypass. Blood is drawn from our patients pre-bypass after obtaining the arterial line and administered back to the patient after separation from cardiopulmonary bypass (CPB) and reversal of heparin with protamine. In our practice we noticed some variability in the impact of ANH on postoperative bleeding; with some patients appearing to show more hemostasis after separation from CPB than others. This is a prospective study to find out if there is an optimal time period that guarantees the largest amount of functioning platelets and what is the best practice for drawing and storing of ANH to guarantee the largest amount of functioning platelets.
Study Type
OBSERVATIONAL
Enrollment
50
Blood is drawn from our patients pre-bypass after obtaining the arterial line and administered back to the patient after separation from cardiopulmonary bypass (CPB) and reversal of heparin with protamine.
Nationwide Children's Hospital
Columbus, Ohio, United States
Time to Platelet Aggregation as Measured Using Collagen-epinephrine (EPI)
The membrane of the cartridges are coated with collagen and epinephrine (EPI) inducing a platelet plug to form which closes the aperture.
Time frame: Just prior to re-transfusion, assessed up to 5 minutes
Time to Platelet Aggregation as Measured Using Collagen-Adenosine (ADP)
The membrane of the cartridges are coated with collagen and adenosine diphosphate (ADP) inducing a platelet plug to form which closes the aperture.
Time frame: Just prior to re-transfusion, assessed up to 5 minutes
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.