The purpose of this study is to understand how simultaneous PET/MR acquisition can provide novel qualitative and quantitative biomarkers to guide clinical intervention and predict prognosis of patients with cardiovascular disease.
* To compare regional myocardial uptake of FDG on images obtained on a standard PET camera with the new PET/MR camera, in patients with coronary artery disease. * To compare viability maps obtained with cardiac MR images and FDG-PET for delineation of myocardial infarct core and border zone, in patients with coronary artery disease. * To correlate MRI myocardial strain with relative myocardial FDG uptake in patients with a previous myocardial infarction. * To interrogate if simultaneous acquisition of cardiac PET and viability cardiac MR differ from acquisitions obtained independently, with special focus on attenuation correction methods * To combined MRI scar map with FDG-PET uptake in patients with cardiac sarcoidosis and myocarditis. * To correlate morphologic characteristics of atherosclerotic disease in the thoracic and abdominal aorta with FDG uptake and ferumoxytol enhancement, as a marker of inflammation. * To evaluate cardiac strain and myocardial scar burden in obese patients with and without diabetes.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
2
PET-MRI with intravenous Gadolinium and FDG. The entire study will take approximately one hour.
UCSF University of California in San Francisco
San Francisco, California, United States
Number of Quality PET and PET/MR Images With Regional Myocardial Uptake of 18F-Fluorodeoxyglucose (FDG) in Participants Without Overt Diagnosis of Ischemic Coronary Artery Disease.
Visual analysis of collected image pairs. Evaluated by experienced imaging providers as yes or no.
Time frame: 2 hours
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