The aim of this study is to investigate the markers of bone mineral metabolism in an unconfounded group of patients with hypogonadism and to search for a relationship between endothelial dysfunction and insulin resistance.
Cardiometabolic disorders are prevalent in patients with hypogonadism. Endothelial dysfunction and insulin resistance are used in determining cardiovascular risk. The role of markers of bone mineral metabolism in hypogonadism is not clearly presented. 49 male patients with hypogonadotropic hypogonadism (HH) and 43 BMI and age matched healthy male subjects were enrolled. Osteoprotegerin (OPG), fibroblast growth factor-23 (FGF-23), vitamin D and asymmetric dimethylarginine (ADMA) levels were measured. The insulin sensitivity was estimated by homeostatic model assessment-insulin resistance (HOMA-IR) formula.
Study Type
OBSERVATIONAL
Enrollment
92
Gulhane School of Medicine
Ankara, Turkey (Türkiye)
Osteoprotegerin, Fibroblast Growth Factor 23 and Vitamin D3 levels
investigate the markers of bone mineral metabolism in patients with hypogonadism
Time frame: one year
relationship between bone mineral metabolism and endothelial dysfunction, insulin resistance
Time frame: one year
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