BRIGHT-SC: Blisibimod Response in IgA Nephropathy Following At-Home Treatment by Subcutaneous Administration

Inclusion Criteria: * 18 - 65 years of age, inclusive * Biopsy-proven IgA nephropathy * Receiving stable, clinically-optimized ACEI and/or ARB * Proteinuria ≥ 1g/24hr but ≤ 6g/24hr at 2 consecutive time points Exclusion Criteria: * Clinical or histologic evidence of non-IgA-related glomerulonephritis * IgA nephropathy with greater than 50% glomerulosclerosis or cortical scarring * Meets eGFR criteria * History of treatment with oral or parenteral corticosteroids within 3 months or immunosuppressants within 6 months * Malignancy within past 5 years * Known to be positive for HIV and/or positive at the screening visit for hepatitis B, or hepatitis C * Liver disease * Neutropenia * Active infection requiring hospitalization or treatment with parenteral antibiotics within the past 60 days or history of repeated herpetic viral infections * History of active tuberculosis or a history of tuberculosis infection * Pregnant or nursing