The purpose of this study is to evaluate the antitussive (cough-suppressing) effects of two liquid medications: a combination of diphenhydramine and phenylephrine in a naturally cocoa flavoring, and, dextromethorphan syrup, compared with placebo.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
22
diphenhydramine 25 mg and phenylephrine 10 mg; dextromethorphan 30 mg; placebo.
diphenhydramine 25 mg and phenylephrine 10 mg; placebo; dextromethorphan 30 mg.
dextromethorphan 30 mg; diphenhydramine 25 mg and phenylephrine 10 mg; placebo
Einstein Division/Montefiore Medical Center
The Bronx, New York, United States
Change in Cough Reflex Sensitivity to Capsaicin
increase in C5 (decrease in cough reflex sensitivity). Capsaicin cough challenge involves subjects breathing in incremental doubling concentrations of aerosolized capsaicin, 1 minute apart, until the concentration of capsaicin (micromolar) inducing 5 or more coughs (C5) is reached.
Time frame: 2 hours after study drug administration
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
dextromethorphan 30 mg; placebo; diphenhydramine 25 mg and phenylephrine 10 mg
placebo; diphenhydramine 25 mg and phenylephrine 10 mg; dextromethorphan 30 mg
placebo; dextromethorphan 30 mg; diphenhydramine 25 mg and phenylephrine 10 mg