Differentiating Everolimus Versus Sirolimus in Combination With Calcineurin Inhibitors in Kidney Transplant Patients

Inclusion Criteria: * Kidney transplant patients ≥ 3 months after transplantation. De novo patients on sirolimus and tacrolimus as well as patients switched to tacrolimus and sirolimus will be eligible as long as they have received this drug combination for at least 2 months. * Immunosuppressive drug regimen based on tacrolimus and sirolimus * 18-70 years of age * calculated glomerular filtration rate≥ 30 mL/min/ 1.73m2 as calculated using the abbreviated Modification of Diet in Renal Disease formula * Ability and willingness to provide written informed consent and adhere to study regimen. * Patients who are able to take oral medication at time of randomization. Exclusion Criteria: * Patients switched to tacrolimus and sirolimus due to clinically relevant nephrotoxicity of the previous immunosuppressive drug regimen, * Patients with an abnormal liver profile such as alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, or total bilirubin \> 3 x upper limit of normal at time of randomization * Patients with severe total hypercholesterolemia (\> 350 mg/dL; \> 9 mmol/L) or total hypertriglyceridemia (\> 500 mg/dL; \> 5.6 mmol/L). Patients on lipid lowering treatment with controlled hyperlipidemia are acceptable. * Patients who tested positive for HIV, Hepatitis C or Hepatitis B surface antigen. * An episode of acute rejection that required antibody therapy or more than one steroid sensitive episode of acute rejection prior to enrollment. * Spot urine protein/creatinine ratio \> 1g/24h at the time of randomization * Multi-organ transplants * Patients with platelet count \< 50,000 * Patients with an absolute neutrophil count of \< 1,000 or white blood cells of \<2,000 at time of enrollment * Patients with hemoglobin \< 6g/dL * Patients with clinically significant systemic infections requiring active use of IV antibiotics, anti-virales, or anti-fungals. Prophylactic use of anti-virales will be acceptable. * Pregnancy or inability of practicing acceptable contraceptive measures. * Patients who have any surgical or medical condition, such as severe diarrhea, active peptic ulcer disease, or uncontrolled diabetes mellitus, which in the opinion of the investigator might significantly alter the absorption, distribution, metabolism and/or excretion of study medication.