-Evaluate the efficacy and safety of Shenyankangfu Tablets to control the proteinuria of patients with primary glomerulonephritis compare with Losartan potassium.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
720
Shenyankangfu tablets 2.4g, po, 3/day and Losartan potassium placebo 2 tab, po, 1/day,all drugs and placebo are taken for 48 weeks.
Shenyankangfu tablets placebo 5 tab, po, 3/day and losartan potassium 50mg,po, 1/day and losartan potassium placebo1 tab,po, 1/day, all drugs and placebo are taken for 48 weeks.
Shenyankangfu tablets 2.4g, po, 3/day and losartan potassium 50mg,po, 1/day and losartan potassium placebo1 tab, po, 1/day, all drugs and placebo are taken for 48 weeks.
changes of 24 hours proteinuria after the treatment
Time frame: 0,4,8,12,24,36,48 weeks after the enrollment
changes of serum creatinine after treatment
Time frame: 0,4,8,12,24,36,48 weeks after the enrollment
changes of eGFR after the treatment
Time frame: 0,4,8,12,24,36,48 weeks after the enrollment
changes of Traditional Chinese Medicine syndrome scores after the treatment
Time frame: 0,4,8,12,24,36,48 weeks after the enrollment
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Shenyankangfu tablets 2.4g, po, 3/day and losartan potassium 50mg×2,po, 1/day, all drugs and placebo are taken for 48 weeks.
Shenyankangfu tablets placebo 5 tab, po, 3/day and losartan potassium 50mg×2,po, 1/day, all drugs and placebo are taken for 48 weeks.
National Clinical Research Center for Kidney Disease, State Key Laboratory of Kidney Disease, Department of Nephrology, Chinese PLA General Hospital
Beijing, Beijing Municipality, China
RECRUITINGBeijing Friendship,Capital Medical University
Beijing, Beijing Municipality, China
RECRUITINGGuang'anmen Hospital, China Academy of Chinese Medical Sciences
Beijing, Beijing Municipality, China
RECRUITINGXIyuan Hospital CACMS
Beijing, Beijing Municipality, China
NOT_YET_RECRUITINGDaping Hospital,Research Institute of Surgery Third Military Medical University
Chongqing, Chongqing Municipality, China
RECRUITINGFuzhou General Hospital Nanjing Military Command
Fuzhou, Fujian, China
RECRUITING174th hospital of the People's Liberation Army
Xiamen, Fujian, China
RECRUITINGGuangdong Province Hospital of Chinese Medical
Guangzhou, Guangdong, China
RECRUITINGGuangzhou First People's Hospital
Guangzhou, Guangdong, China
RECRUITINGBeidaihe Sanatorium of Beijing Military Mrca
Qinhuangdao, Hebei, China
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