NCT02063282 - The Risk for Clostridium Difficile Colitis During Hospitalization in Asymptomatic Carriers | Crick

Overview

The investigators hypothesize that development of symptoms characteristic of Clostridium difficile infection will be 2-3 times higher in asymptomatic carriers, compared to that of non carriers and expect to find risk factors for development of symptomatic clostridium difficile.

Study Type

OBSERVATIONAL

Enrollment

394

Conditions

Clostridium Difficile Colitis

Eligibility

Sex: ALLMin age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * History of hospitalization in recent year, residence of a nursing home or institutions * Expected more than 48 hours hospitalization Exclusion Criteria: * Colitis/ diarrhea * Rectal swab performed ≥48 hrs post arrival to hospital.

Locations (1)

Shaare Zedek Medical Center

Jerusalem, Israel

Outcomes

Primary Outcomes

Development of colitis

participants will be followed for the duration of hospital stay, an expected average of 4 weeks. Patients' file will be reviewed and the next signs and symptoms will be recorded: abdominal pain, diarrhea, fever and leukocytosis.

Time frame: Daily follow-up

Secondary Outcomes

Duration until development of colitis

participants will be followed for the duration of hospital stay, an expected average of 4 weeks. Patients' file will be reviewed and the next signs and symptoms will be recorded: abdominal pain, diarrhea, fever and leukocytosis.

Time frame: Daily follow-up

Severity of colitis

participants will be followed for the duration of hospital stay, an expected average of 4 weeks. Patients' file will be reviewed and the next signs and symptoms will be recorded: abdominal pain, diarrhea, fever and leukocytosis.

Time frame: Daily follow-up