CSF Cholinergic Biomarkers and Postoperative Cognitive Change

N/ACompletedNCT02063542

RenJi Hospital102 enrolled

Overview

Previous study demonstrated that the condition of central cholinergic nerve is important for the postoperative cognitive dysfunction. In present study investigators hypothesized that the acetylcholine concentration in the cerebral spinal fluid is associated to the postoperative cognitive changes in aged patients undergoing osteopathic surgery.

Study Type

OBSERVATIONAL

Enrollment

102

Conditions

Necrosis of Femoral Head Knee Osteoarthritis Fracture of Lower Limb

Eligibility

Sex: ALLMin age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Elder than 60 years old * Spoke proficient Mandarin Chinese * Agree to undergoing spinal plus general anesthesia * Selected total knee replacement surgery Exclusion Criteria: * Patients with neurological and/or psychiatric diseases, including AD, stroke and psychosis * Have contraindication for spinal anesthesia such as clotting disorder local infection in the puncture site * Existing cognitive impairment as evidenced by Mini-Mental State Examination scores below 24 * Several audition or vision disorder * Unwillingness to comply with the protocol or procedures.

Locations (1)

Renji hospital, School of Medicine, Shanghai Jiaotong University

Shanghai, Shanghai Municipality, China

Outcomes

Primary Outcomes

Short-term postoperative cognitive dysfunction rate

Time frame: The day before surgery and 7 days after surgery (or before leave hospital)

Concentration of Acetylcholine in CSF

Time frame: During spinal anesthesia

Concentration of choline acetyltransferase in CSF

Time frame: During spinal anesthesia

Concentration of acetylcholinesterase in CSF

Time frame: During spinal anesthesia

Secondary Outcomes

Long-term postoperative cognitive dysfunction rate

Time frame: Two months after surgery

Data from ClinicalTrials.gov

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