Active Bathing to Eliminate Infection (ABATE Infection) Trial

N/ACompletedNCT02063867

University of California, Irvine53 enrolled

Overview

The ABATE Infection Project is a cluster randomized trial of hospitals to compare two quality improvement strategies to reduce multi-drug resistant organisms and healthcare-associated infections in non-critical care units. The two strategies to be evaluated are: * Arm 1: Routine Care Routine policy for showering/bathing * Arm 2: Decolonization Use of chlorhexidine as routine soap for showering or bed bathing for all patients Mupirocin x 5 days if MRSA+ by history, culture, or screen Note that enrolled "subjects" represents 53 individual HCA Hospitals (representing \~190 non-critical care units) that have been randomized.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Enrollment

Conditions

Healthcare Associated Infections Methicillin Resistant Staphylococcus Aureus Multi Drug Resistant Organisms

Arm 2: DecolonizationDRUG

Daily chlorhexidine (CHG) shower or CHG cloth bath for all non-critical care patients. Topical intranasal mupirocin ointment (bilateral nares, twice daily) x5 days if non-critical care patients are MRSA+ by history, culture, or screen.

Eligibility

Sex: ALLMin age: 12 Years

Medical Language ↔ Plain English

Inclusion Criteria: * All HCA hospitals that reside in the United States * Note: Unit of randomization is the hospital, but the participants are hospital units Exclusion Criteria: * Non-critical care units where chlorhexidine bathing or decolonization for MRSA+ non-critical care patients is routine * Pediatric, peri-partum, rehabilitation, psychiatry, and BMT units * Units with \>30% cardiac or hip/knee orthopedic surgeries * Unit average length of stay \<2 days * Patients \<12 years-old * Patients with known allergy to mupirocin or chlorhexidine

Locations (52)

West Hills Hospital & Medical Center

West Hills, California, United States

North Suburban Medical Center

Thornton, Colorado, United States

Blake Medical Center

Bradenton, Florida, United States

Osceola Regional Medical Center

Kissimmee, Florida, United States

Palms West Hospital

Loxahatchee Groves, Florida, United States

Outcomes

Primary Outcomes

MRSA and VRE Clinical Cultures

Methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) clinical cultures attributable to participating units. Defined as occurring \>2 days into a participating unit stay through 2 days following unit discharge

Time frame: 21 months

Secondary Outcomes

Gram-negative Multi-drug Resistant Organism Clinical Cultures

Gram-negative (GN) multi-drug resistant organism clinical cultures attributable to participating units. Defined as occurring \>2 days into a participating unit stay through 2 days following unit discharge

Time frame: 21 months

All-cause Bloodstream Infections

All-cause bloodstream infections attributable to participating units. Defined as occurring \>2 days into a participating unit stay through 2 days following unit discharge. Includes bacterial and yeast pathogens. Skin commensals require two positive blood cultures.

Time frame: 21 months

Active Bathing to Eliminate Infection (ABATE Infection) Trial

Overview

Conditions

Interventions

Eligibility

Locations (52)

Outcomes

Primary Outcomes

Secondary Outcomes