Association Between Confocal Laser Endomicroscopic (CLE) Features and Colorectal Mucosal Microbiome

N/ACompletedNCT02063919

Shandong University45 enrolled

Overview

The purpose of this study is to determine whether an association between endomicroscopic pattern and colorectal mucosal microbiome exists.

The gut microbiome plays a pivotal role in the intestinal pathophysiology. The mucosal microbiome is in the front face of microbiome-host cross-talk. Confocal laser endomicroscopy (CLE) can provide realtime mucosal images during ongoing endoscopy. We hypothesized that the mucosal pattern, here evaluated by endomicroscopy, may constitute specific microbiome niches and participate the evolvement of the mucosal microbiome.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Colorectal Neoplasia Colorectal Inflammation Hyperplasia Mucosal Microbiome

Interventions

the mucosal microbiome in the biopsy specimen was analysedOTHER

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 18 years old ≤ age \< 80 years old * Scheduled for colonoscopy in Qilu Hospital Exclusion Criteria: * antibiotic usage within 2 months * probiotic or prebiotic usage within 2 months * ascites * jaundice * liver cirrhosis * impaired renal function * coagulopathy * fever * pregnancy * breastfeeding * inability to provide informed consent * known allergy to fluorescein sodium

Locations (1)

Department of Gastroenterology, Qilu Hospital, Shandong University

Jinan, Shandong, China

Outcomes

Primary Outcomes

The operational taxonomy unit in the colorectal mucosal microbiome.

Time frame: 6 months

Data from ClinicalTrials.gov

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