Association Between Confocal Laser Endomicroscopic (CLE) Features and Gastric Mucosal Microbiome

N/AUnknownNCT02063932

Shandong University60 enrolled

Overview

There might be a correlation between gastric mucosal microbiome and mucosal pattern visualized by confocal laser endomicroscope.

The gastric mucosal microbiome plays a pivotal role in a series of diseases, such as the H.pylori infection. We hypothesized that mucosal patterns, here visualized by confocal endomicroscopy, may constitute specific microbiome niches.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Mucosal Microbiome H.Pylori Intestinal Metaplasia Gastric Neoplasia

Interventions

endomicroscopy, targeted biopsy and 16s rRNA gene sequencingOTHER

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion criteria: * Patients scheduled for gastroendoscopy examination * Aged between 18 and 80 years old Exclusion criteria: * Antibiotic, probiotic or prebiotic usage within 2months * Esophageal, gastric or duodenal cancer or other malignancy * History of upper GI tract surgery * Coagulopathy or bleeding disorders * Allergy to fluorescein sodium * Pregnant or breast-feeding (for females) * Impaired renal function

Locations (1)

Department of Gastroenterology, Qilu Hospital, Shandong University

Jinan, Shandong, China

RECRUITING

Outcomes

Primary Outcomes

The operational taxonomy units in gastric mucosal microbiome

Time frame: 6 months

Secondary Outcomes

The diagnostic accuracy of endomicroscopy compared to pathology.

Time frame: 6 months

Data from ClinicalTrials.gov

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