Stereotactic Boost and Long-Term Androgen Deprivation for Adenocarcinoma of the Prostate

Inclusion Criteria: 1. Pathologically (histologically or cytologically) proven diagnosis of prostatic adenocarcinoma within 180 days of registration at moderate to high risk for recurrence 2. History/physical examination (to include at a minimum digital rectal examination of the prostate and examination of the skeletal system and abdomen) within 90 days prior to registration. 3. Clinically negative lymph nodes as established by imaging (pelvic ± abdominal CT or MRI), (but not by nodal sampling, or dissection) within 90 days prior to registration. 4. Patients with lymph nodes equivocal or questionable by imaging are eligible if the nodes are ≤ 2.0 cm. 5. No evidence of bone metastases (M0) on bone scan within 90 days prior to registration. 6. Equivocal bone scan findings are allowed if plain films (or CT or MRI) are negative for metastasis. 7. Baseline serum PSA value performed with an FDA-approved assay (e.g., Abbott, Hybritech) within 12 weeks (90 days) prior to registration. 8. Study entry PSA should not be obtained during the following time frames: (1) 10-day period following prostate biopsy; (2) following initiation of hormonal therapy; (3) within 30 days after discontinuation of finasteride; (4) within 90 days after discontinuation of dutasteride. 9. Zubrod Performance Status 0-2 10. Complete blood count (CBC)/differential obtained within 2 weeks (14 days) prior to registration on study, with adequate bone marrow function 11. Patient must be able to provide study specific informed consent prior to study entry. Exclusion Criteria: 1. Prior invasive (except non-melanoma skin cancer) malignancy unless disease-free for a minimum of 2 years. 2. Previous radical surgery (prostatectomy) or cryosurgery for prostate cancer 3. Previous pelvic irradiation, prostate brachytherapy, or bilateral orchiectomy 4. Previous hormonal therapy 5. Prior pharmacologic androgen ablation for prostate cancer is allowed only if the onset of androgen ablation is ≤ 60 days prior to the date of registration. 6. Use of finasteride within 30 days prior to registration 7. Use of dutasteride or dutasteride/tamsulosin (Jalyn) within 90 days prior to registration 8. Previous or concurrent cytotoxic chemotherapy for prostate cancer; note that prior chemotherapy for a different cancer is allowable. See Section 3.2.1. 9. Prior radiotherapy, including brachytherapy, to the region of the study cancer that would result in overlap of radiation therapy fields 10. Severe, active co-morbidity including heart issues, infection and liver problems 11. Patients who are sexually active and not willing/able to use medically acceptable forms of contraception 12. Prior allergic reaction to the hormones involved in this protocol 13. Patients status-post a negative lymph node dissection are not eligible