This trial is conducted in Europe. The aim of the trial is to evaluate the effect of semaglutide on cardiac repolarisation in healthy subjects.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
168
Solution for subcutaneous (s.c., under the skin) injection. Dose escalation to 1.5 mg.
Solution for s.c. injection or tablets for oral administration
Tablets for oral administration
Novo Nordisk Investigational Site
Berlin, Germany
QTcI, (Individual heart rate corrected QT (Interval in the ECG: from the start of the QRS complex to the end) interval) based on ECG recordings obtained at 11 time points
Time frame: 0-48 hours after the fourth dose of semaglutide/semaglutide placebo at the 1.5 mg dose level
QTcI, based on ECG (electrocardiogram) recordings obtained at 2 out of 8 time points
Time frame: 0-24 hours after a single dose of moxifloxacin/moxifloxacin placebo
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