High Intensity Cycling Before SCUBA Diving Reduces Post-decompression Microparticle Production and Neutrophil Activation

N/ACompletedNCT02064361

University of Split10 enrolled

Overview

The purpose of this study is to determine the impact of high intensity,anaerobic exercise, in the form of cycling, on SCUBA diving. Outcomes are determined by the quantification and subtype of circulating microparticles, complete blood counts, and the quantification of venous gas emboli, measured via transthoracic echocardiography, in the cardiac cavities.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Decompression Sickness SCUBA Diving

Interventions

High intensity exerciseOTHER

Subjects performed a repeated Wingate protocol for the exercise condition of the study. This consisted of 4, 30 s maximal efforts on a weight-braked cycle ergometer (Monark 894E, Monark Exercise AB, Sweden) with 4 min active recovery between efforts, preceded by a 5 min warm up. The resistance was set at 7.5% bodyweight for the intervals and 2% for the warm up and active recovery periods.

Eligibility

Sex: MALEMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Experienced divers (\> 250 logged dives) * Male * Physician clearance to dive Exclusion Criteria: * Prior incidence of decompression sickness

Locations (2)

University of Maryland

Baltimore, Maryland, United States

University of Split School of Medicine

Split, Dalmatia, Croatia

Outcomes

Primary Outcomes

Change from baseline values of number of circulating microparticles per microliter of blood

Time frame: Prior to exercise, prior to diving, 15 and 120 minutes after surfacing

Data from ClinicalTrials.gov

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