The Bioequivalence Study of Lamotrigine Dispersible/Chewable Tablets 100mg Compared With Compressed Tablet 100 mg

Inclusion Criteria: * Healthy Chinese male non-smoker, based on medical history and physical examination, aged between 18 and 45 years of age inclusive, at the time of signing the informed consent. * Healthy as determined by a responsible and experienced physician, based on a medical evaluation including medical history, physical examination, laboratory tests and cardiac monitoring. A subject with a clinical abnormality or laboratory parameter(s) which is/are not specifically listed in the inclusion or exclusion criteria, outside the reference range for the population being studied may be included only if the Investigator (in consultation with the GlaxoSmithKline (GSK) Medical Monitor if required) agree and document that the finding is unlikely to introduce additional risk factors and will not interfere with the study procedures. * Body weight \>= 50 kg and BMI within the range 19 - 24 kg/m2 (inclusive). * Capable of returning to study site for follow-up according to the requirement of protocol and willing to comply with the policy, procedure and restriction of the study. * Capable of reading and understanding the information listed in the consent form. Signing the informed consent prior to any study related procedure. * Aspartate transaminase (AST), Alanine transaminase (ALT), alkaline phosphatase (ALP) and total bilirubin \<= 1.5✕Upper limit of normal (ULN) (total bilirubin \>1.5 x ULN alone is acceptable if direct bilirubin \<35% of total bilirubin). * Normal blood pressure (systolic blood pressure 90-140 mmHg, inclusive, diastolic blood pressure \< 90mmHg) and pulse rate (60-100, inclusive). * No clinically significant abnormality on 12-lead ECG. * Corrected QT interval (QTc) \< 450 ms; or corrected QT interval \< 480 ms for subjects with bundle-branch block, based on single or averaged QTc values of triplicate ECGs obtained over a brief recording period. * Male subjects with female partners of child-bearing potential must use one of the contraceptive methods after the first dose of study treatment and until the follow-up visit. Exclusion Criteria: * Current or chronic history of cardiovascular, respiratory, gastrointestinal, endocrine, hematological, psychical or nervous system diseases, use of drug that can change the absorption, metabolism or elimination of study drug, or result in danger or other drugs or diseases that interfere with the interpretation of study data. * Current or chronic history of liver disease, or known hepatic or biliary abnormalities or Gilbert's syndrome (with the exception of asymptomatic gallstones). * Current or past history of nervous-psychiatric disorder, as assessed by Columbia Suicide Severity Rating Scale-baseline evaluation or in the opinion of investigator that the subject is at risk of suicide or with history of suicide behavior/attempt. * History of regular alcohol consumption within 6 months of the study defined as: an average weekly intake of \>14 drinks. One drink is equivalent to 12 g of alcohol: 12 ounces (360 ml) of beer, 5 ounces (150 ml) of wine or 1.5 ounces (45 ml) of 80 proof distilled spirits. * Consumption of grapefruit or grapefruit juice within 7 days prior to first dose of study medication. * History of sensitivity to heparin or heparin-induced thrombocytopenia. * History of asthma, anaphylaxis or anaphylactic reactions, severe allergic responses. * Subjects who have received lamotrigine previously (subjects who received placebo in a previous study will be allowed) * History of sensitivity to any of the study medications, or components thereof or a history of drug or other allergy that, in the opinion of the investigator or GSK Medical Monitor, contraindicates their participation. * Unable to refrain from the use of prescription or non-prescription drugs, including vitamins, herbal and dietary supplements (including St John's Wort) within 14 days prior to the dosing day, which in the opinion of the Principal Investigator, may interfere with the study procedures or compromise safety. * A positive Hepatitis B surface antigen (HBsAg) or positive Hepatitis C antibody (HCAb) result at screening * A positive pre-study drug/alcohol screen. * A positive test for HIV antibody at screening. * Where participation in the study would result in donation of blood or blood products in excess of 500 mL within a 56 day period. * The subject has participated in a clinical trial and has received an investigational product within the following time period prior to the first dosing day in the current study: 30 days, 5 half-lives or twice the duration of the biological effect of the investigational product (whichever is longer). * Exposure to more than four new chemical entities within 12 months prior to the first dosing day. * Unwillingness or inability to follow the procedures outlined in the protocol.