Enzalutamide and Hormone Therapy Before, During, and After Radiation for High Risk Localized Prostate Cancer

Inclusion Criteria: * histologically proven adenocarcinoma of the prostate within 6 months of screening * Eastern Cooperative Oncology Group(ECOG) score 0-2 * adequate organ and and blood marrow function * must be a candidate for long-term androgen deprivation in combination with external beam radiation for the treatment of high risk prostate cancer * patient must permit a targeted prostate biopsy at the time of study initiation or at the beginning of radiation treatment * men who are sexually active with female partners of child-bearing potential mush agree to use adequate contraception Exclusion Criteria: * prior treatment with agents known to have endocrine effects on prostate cancer * treatment with corticosteroids within 4 weeks of enrollment * treatment with androgens within 6 months of enrollment * may not be receiving any other investigational agents * Prostate specific antigen greater than 160ng/dL * history of malignancy( other than non-melanoma skin cancer) within 5 years * uncontrolled intercurrent illness * cardiovascular event within 6 months of enrollment * seizure or seizure disorder history * contraindications to MRI- pacemakers, clips, etc