High Omega-3/Low Omega-6 Treatment Diet for Aspirin-exacerbated Respiratory Disease (AERD)

Inclusion Criteria: * History of physician-diagnosed asthma * History of nasal polyposis * History of at least two reactions to oral aspirin or other nonselective cyclooxygenase inhibitor with features of lower airway involvement (cough, chest tightness, wheezing, dyspnea), or diagnosis of AERD via a physician-conducted challenge to aspirin * Age between 18 and 70 years Exclusion Criteria: * Current smoking, defined as daily tobacco smoking in the last 6 months and at least one instance of tobacco smoking in the last 3 months. * Current pregnancy or breastfeeding * BMI \<20 * History of allergy to fish or any unwillingness to eat fish as a regular part of the diet * Use of Zyflo (zileuton) in the last two weeks * Presence of an implantable cardioverter-defibrillator * Use of oral steroids in the last two weeks * Participation in any other clinical trial in the last month * Any use of nonsteroidal antiinflammatory drugs (NSAIDs) or any drug that inhibits the cyclooxygenase enzyme during the course of the study