Carbon Monoxide's Headache Inducing Characteristics and Effects on the Cerebral Arteries and Blood Flow

N/ACompletedNCT02066558

Danish Headache Center12 enrolled

Overview

In this study the investigators will research the hypothesis that the gas carbon monoxide induces headache and increases the blood flow velocity in the middle cerebral artery.

To investigate headache score and accompanying symptoms during and after inhalation of carbon monoxide. With transcranial Doppler imaging, c-scan and laser speckle the investigators will investigate changes in blood flow velocity of the middle cerebral artery (MCA), diameter of the superficial temporal artery (STA), the radial artery and facial skin perfusion.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

QUADRUPLE

Enrollment

Conditions

Headache Migraine

Interventions

Carbon monoxideOTHER

carbon monoxide, 4.7, Purity 99.997, inhalation of carbon monoxide in a volume corresponding to carboxyhemoglobin 10 and 20%, calculated from baseline Hg and body mass.

PlaceboOTHER

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy volunteers * Aged 18-50 * 50-100 kg Exclusion Criteria: * Tension type headache more than once/month * Other primary headaches * Daily medication except contraceptives * Drug taken within 4 times the halflife for the specific drug except contraceptives * Pregnant or lactating women * Exposure to radiation within the last year * Headache within the last 24 hours before start of trial * Hypertension * Hypotension * Respiratory or cardiac disease * Smoking * Primary relatives with current or previous migraine

Locations (1)

Danish Headache Center

Glostrup Municipality, Denmark, Denmark

Outcomes

Primary Outcomes

Headache scores

Comparison between carbon monoxide and placebo (atmospheric air)

Time frame: 12 h

Secondary Outcomes

Blood flow velocity

Carbon monoxide induced changes in blood flow velocity in the middle cerebral artery before and after inhalation.

Time frame: 0-180 min after inhalation

Artery circumference

Carbon monoxide induced changes in the superficial temporal artery and the radial artery before and after inhalation.

Time frame: 0-180 min

Facial blood flow

Carbon monoxide induced changes in facial blood flow before and after inhalation.

Time frame: 0-180 min

Data from ClinicalTrials.gov

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