Epidural Low Dose Morphine in Postoperative Pain After Posterior Lumbar Spinal Surgery

Phase 4CompletedNCT02067338

Mahidol University19 enrolled

Overview

The effect of epidural low-dose morphine-soaked microfibrillar collagen sponge in postoperative pain control after posterior lumbar spinal surgery: a randomized, double-blind, placebo-controlled study

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Morphine

Interventions

1 mg morphine soak in epidural oxidized celluloseDRUG

During posterior lumbar spinal surgery , patients received 1 mg morphine-soaked in epidural oxidized cellulose.

normal salineDRUG

During posterior lumbar spinal surgery , patients received NSS -soaked in epidural oxidized cellulose.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age \> 18 Yrs * Good orientation and communication Exclusion Criteria: * opioids or sulfonamides allergy * Contraindication for use * Epidural morphine * Selective COX 2 inhibitor * Patient-controlled analgesia (PCA) * ASA class \> 3 * BMI ≥ 35 kg/sq.m. * Preoperative use of opioids within 6 Wks * Intraoperative bleeding \> 1000ml

Locations (1)

Siriraj hospital

Bangkoknoi, Bangkok, Thailand

Outcomes

Primary Outcomes

VAS measurement was recorded at twenty-four hour after posterior lumbar spinal surgery then compare VAS between low-dose 1 mg morphine-soaked microfibrillar collagen sponge method with normal saline soked

Time frame: 2 years

Data from ClinicalTrials.gov

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