Predictive Biomarkers For Pediatric Chronic Graft-Versus-Host Disease

Inclusion Criteria: 1. Allogeneic hematopoietic stem cell transplantation for any malignant or non-malignant disease. 2. Age 0-17.99 years at the time of transplantation. 3. Bone marrow, peripheral blood stem cell and umbilical cord blood (including single or double cord blood) as the graft source. 4. Any conditioning regimen with any chemotherapy / radiation therapy combination. Haploidentical donor transplants with post-transplant cyclophosphamide are also allowed. 5. Use of serotherapy is permitted. 6. Any graft-versus-host disease prophylaxis is permitted, including post-HSCT cyclophosphamide. 7. If participant weighs between 0-20 kg, participant must be able to provide 15 ml of whole blood at each time point. 8. If participant weighs over 20 kg, participant must be able to provide 1ml/kg of whole blood, up to a maximum of 23 mL for the pre-conditioning sample and 32 mL for samples at day +100, 6-months, 12-months, +/- the cGVHD sample. 9. Written informed consent from parents. 10. Assent from study participant when appropriate. 11. Participation on other clinical trials is acceptable. Exclusion Criteria: 1. Autologous HSCT. 2. Patients referred to a Bone Marrow Transplant (BMT) center from a non-BMT center, where it is anticipated (at the discretion of the center PI) that adequate follow up according to the rules of this protocol can not be met, including the requirement for a reassessment by the BMT center at the time of cGVHD diagnosis. 3. Ex-vivo T-cell depletion of graft source (e.g. CD34 selection). 4. Second (or greater) allogeneic transplants (first allogeneic transplant where a previous autologous transplant was performed is permitted). 5. Syngeneic transplants.