Changes in Food Preference and Food Cue Responsivity After Bariatric Surgery

N/AUnknownNCT02068001

Wageningen University100 enrolled

Overview

It has been suggested that obese people are more sensitive to sensory and rewarding effects of food, aspects that mediate food preferences and intake. Individuals that underwent Roux-en-Y gastric bypass surgery frequently report changes in food preference. They indicate a decreased preference for highly rewarding energy dense foods. Changes in food preference might be related to alterations in central (brain) mechanisms, related to reward sensing. The smell and sight of food can be considered as anticipatory cues for the rewarding effects of food intake. The aim of this study is to determine the effect of gastric bypass surgery on (alterations in) food preferences. Secondly, this study aims at assessing the effect of gastric bypass surgery on the brain reward response when exposed to sight and smell of food stimuli with different sugar and fat contents.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Roux-en-Y Gastric Bypass

Interventions

Roux-en-Y Gastric BypassPROCEDURE

Eligibility

Medical Language ↔ Plain English

Inclusion Criteria: * Scheduled for Roux-en-Y Gastric Bypass Surgery at Rijnstate hospital Exclusion Criteria: * Lack of appetite * Having difficulties swallowing/eating * Being a vegetarian * Allergic to food product used as stimuli in the study

Locations (3)

Rijnstate Hospital

Arnhem, Gelderland, Netherlands

Gelderse Vallei Hospital

Ede, Gelderland, Netherlands

Wageningen University

Wageningen, Gelderland, Netherlands

Outcomes

Primary Outcomes

Development of food preferences after Roux-en-Y gastric bypass surgery

Food preferences will be assessed 2 weeks before Roux-en-Y Gastric Bypass surgery and 2 months, 1 year and 2 years after surgery.

Time frame: Participants will be followed for two years after they undergo surgery

Change in brain reward response to food cues

Two weeks before and two months after Roux-en-Y Gastric Bypass the brain reward response to the sight and smell of food will be assessed in a subset of 30 participants.

Time frame: Before and 2 months after surgery

Secondary Outcomes

Plasma levels of endocannabinoids and satiety hormones

Two weeks before and two months after Roux-en-Y gastric bypass surgery, fasted plasma levels of endocannabinoids, ghrelin, leptin, adiponectin and Glucagon-Like Peptide will be assessed in a subset of 30 participants.

Time frame: Before and 2 months after surgery