A Study of ALKS 5461 in Healthy Volunteers

Inclusion Criteria: * Be in good physical health * Body mass index of 18-30 kg/m2 * Agree to use an approved method of birth control for the duration of the study * Additional criteria may apply Exclusion Criteria: * Currently pregnant or breastfeeding * History of or current infection with Hepatitis B Virus, Hepatitis C Virus or Human Immunodeficiency Virus (HIV) * Current or history of any clinically significant medical or psychiatric condition * Current abuse or dependence on alcohol or any illicit drugs * Have used nicotine within 90 days * Have used St. John's Wort or consumed grapefruit, grapefruit juice, or juices containing grapefruit within 30 days * Have used any prescription or over-the-counter medication, including natural health products (with the exception of prescription birth control or hormonal replacements, acetaminophen, ibuprofen, or multivitamins) within 14 days * Have used opioids 30 days prior to screening or have an anticipated need for opioid medication at any point during the study * Have a history of intolerance or hypersensitivity to buprenorphine or opioid antagonists (eg, naltrexone, naloxone) * Additional criteria may apply