The Effect of Cranberry Extract Supplementation on Cardiovascular Risk Factors in Obese, Insulin Resistant Humans

Inclusion Criteria: * Are 20 years of age or older * Not being treated with diabetes medication. However, if you are taking Metformin for pre-diabetes and are willing to stop taking the medication 2 weeks before and during the study that is ok. We will request clearance from your prescribing physician prior to stopping metformin and enrolling in the study. * Have a blood sugar of 100-125 mg/dL (fasting) or 140-199 mg/dL after a 2 hour glucose tolerance test (determined by tests done at the screening visit) * Have a fasting insulin more than or equal to 5 µIU/ml (determined by tests done at the screening visit) * Have a Body Mass Index (BMI) ≥ 30 and ≤ 45. Exclusion Criteria: * Have a prior history of type 2 diabetes * Are pregnant or breastfeeding. * Are a woman able to have children and are not using birth control (i.e. barrier method, intrauterine and cervical devices, birth control pills, hormonal injections (Depo Provera® ), condoms with spermicidal gel or foam, contraceptive patch (Ortho Evra), diaphragm, or abstinence), or have had a tubal ligation or hysterectomy, or not at least 2 years past menopause. \- All women able to have children will have a pregnancy test at the screening visit. If you become pregnant during the study, you will be dropped from the study. * Have type 1 diabetes. * Are taking steroids (except topical or inhaled steroids). \- Other medications that may affect your blood sugar (i.e. certain blood pressure medications) are acceptable if the dose has not changed in the previous 6 months and the dose will not change during the study. * Have a history or evidence of stomach or intestinal problems, e.g. irritable bowel syndrome; inflammatory bowel disease; ulcerative colitis or Crohn's disease; diverticulosis or diverticulitis; narrowing of the intestines, partial or complete removal of the stomach or small bowel; autonomic neuropathy consisting of difficulty swallowing; delayed stomach emptying or diarrhea; chronic, severe constipation; stomach or colon ulcers, or GI bleeding. * Use laxatives or cathartics on a chronic basis. * Take medications known to damage the kidneys, such as certain antibiotics, methicillin, and cyclosporin. * Have any evidence of kidney disease. * Have significant heart problems and/or history (within the last 6 months) of significant heart problems. * Have evidence within the previous 6 months of liver disease such as hepatitis; jaundice; cirrhosis. * Have clinically significant lung, neurologic, blood-related, immune system-related, cancer-related or metabolic disease. * Have had a recurrence of cancer within the past five years, other than treated basal cell carcinoma. * Are planning surgery during the study period. * Have a history of substance abuse or alcoholism within the past 5 years, or significant psychiatric disorder that would interfere with your ability to complete the study. * Have donated blood during the month before entering the study or are planning to donate blood during the study. * Have participated in other studies using a research medication during the previous 3 months. * Are currently smoking or have smoked within the past 6 months. \- No smoking will be allowed during the study. * Have had a fluctuation in body weight \>5% in the previous 2 months. * Are taking prescription or over-the-counter medication for weight loss. * Are taking weight loss or herbal supplements. * Are taking prescription or over-the-counter anti-inflammatory medications (such as naproxen, aspirin, ibuprofen). * Are allergic to cranberries