Dithiolethiones, a novel class of adenosine monophosphate-activated protein kinase (AMPK) activators, prevent insulin resistance through AMPK-dependent p70 ribosomal S6 kinase-1 (S6K1) inhibition. And it is well known that the modulation of S6K1 by oltipraz inhibited the development of insulin resistance and hyperglycemia through the AMPK-S6K1 pathway.Also some research reported that LXRg (a member of the nuclear hormone receptor)-mediated increases in SREBP-1c (the sterol regulatory element-binding protein-1c gene) promote the expression of lipogenic genes and enhance fatty acid synthesis and oltipraz inhibits LXRg and SREBP-c. Therefore, Oltipraz inhibits fatty acid synthesis through AMPK-S6K1 pathway and LXRg-SREBP-1c pathway in liver.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
283
NHUS Ilsan Hospital
Ilsan-ro Ilsan-donggu, Goyang-si, South Korea
Inje University Ilsan Paik Hospital
Dahwa-dong, Ilsanseo-gu, Goyang-si, Gyeonggi-do, South Korea
Seoul National University Hospital
Daehak-ro Jongno-gu, Seoul, South Korea
Korea University Guro hospital
Gurodong-ro, Seoul, South Korea
Boramae Hospital
Sindaebang-dong Dongjak-gu, Seoul, South Korea
MRS(magnetic resonance spectroscopy)
To evaluate the efficacy of the Oltipraz on change in quantity of liver fat (% change) assessed by MRS from baseline to 24 weeks in patients.
Time frame: 24 weeks
change in liver fat concentration
Time frame: 24 weeks
change in BMI
Time frame: 8, 16, 24 weeks
change in NAFLD Fibrosis score (NFS)
Time frame: 24 weeks
change in ALT, AST, γ-GT
Time frame: 8, 16, 24 weeks
change in Cholesterol (total, LDL, HDL, VLDL), Triglyceride (TG)
Time frame: 8, 16, 24 weeks
change in HOMA-IR
Time frame: 8, 16, 24 weeks
change in waist circumference
Time frame: 24 weeks
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