The objective of the study is to determine the relative roles for various testing modalities in the diagnosis and prognosis of mild traumatic brain injury.
Subjects will undergo functional brain testing (magnetoencephalography, electroencephalography), anatomical brain imaging (diffusion tensor imaging, susceptibility-weighted imaging), neuropsychological testing (memory, language, processing speed), sleep patterns using actigraphy, and blood testing of candidate biomarkers. Testing will be done at 3 time points post-injury: 1 day, 14 days, and 30 days post-injury. Analysis of these tests collectively will be used to develop diagnostic tools for acute mTBI.
Study Type
OBSERVATIONAL
Enrollment
44
Huntington Medical Research Institutes
Pasadena, California, United States
HMRI
Pasadena, California, United States
Molecular Neurology Program
Pasadena, California, United States
Change in objective measures of brain function (MEG/EEG, blood biomarkers)
For MEG/EEG, resting state analyses of brain function will be conducted to include frequency band analyses localizing, for example, delta slow wave activity, and establishing functional connectivity scores at three time points post injury (day 1, day 14, day 30). For blood biomarkers, serum levels in approximately ten biomarkers will be measured to determine amount in each and if changes occur at three time points post-injury.
Time frame: Day 1, day 14, and day 30 post-injury
Change in anatomical measures of brain function (DTI, SWI)
Diffusion Tensor-derived measures will be calculated for control and mTBI participants to determine if changes occur at three time points post-injury (day 1, day 14, day 30).
Time frame: Day 1, day 14, and day 30 post-injury
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