Pharmacokinetic Interactions Between Amlodipine Besylate/Valsartan and Atorvastatin in Healthy Male Subjects

Inclusion Criteria: 1. Male volunteers in the age between 20 and 45 years old 2. The weight is over 55kg and is not exceed ±20% of ideal weight Ideal weight = \[height -100\]\*0.9 3. Subjects with no history of any significant chronic disease 4. Judged to be in good health on the basis of routine laboratory data obtained prior to study drug administration 5. Willing to adhere to protocol requirements and sign a informed consent form Exclusion Criteria: 1. Subjects with Symptoms of acute disease within 28days prior to study medication dosing 2. Subjects with a history of gastrointestinal diseases which might significantly change ADME of medicines 3. Subjects with a history of clinically significant allergies including drug allergies or anaphylaxis to amlodipine, valsartan and/or atorvastatin 4. Subjects with a history of myopathy 5. Subjects with a hereditary problems, for example, galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption 6. Subject with the mean blood pressure of siDBP ≥ 150 mmHg or ≤ 90 mmHg and/or siSBP ≥ 95 mmHg or ≤ 50 mmHg at the screening visit 7. Subjects with abnormal HDL-cholesterol(\<35mg/dL) 8. Subjects with abnormal of serum potassium concentration (\<3.4 mEq/L of \>5.5 mEq/L in screening visit) 9. Subjects with a history of drug abuse 10. Subjects taking inducer or inhibitor of drug metabolism enzyme such as barbital within 28days prior to study medication dosing 11. Subjects who have received any drugs that might confound the results of the trial based on medical judgement by investigators within 14days prior to drug administration and OTC or vitamin within 7days prior to drug administration 12. Participated in a previous clinical trial within 60 days prior to dosing 13. Donated blood within 60 days prior to dosing 14. Subjects with a history of alcohol abuse(over 21 units/week, 1 unit = 10 g of pure alcohol) or is difficult to stop drinking within study 15. Subjects have ever smoked over 10 cigarette per day within 3 months prior to drug administration 16. Subjects with a history of caffeine abuse or or is difficult to stop drinking within study 17. Subjects with biliary obstruction 18. Subjects with hepatic dysfunction (AST or ALT \>3 times to accepted normal range) 19. Subjects with moderate renal dysfunction (creatinine clearance (CLcr) \< 30mL/min) 20. Subjects considered as unsuitable based on medical judgement by investigators