Cellular Reprogramming-Enhanced Skin Grafting for Diabetic Foot Ulcers

Inclusion Criteria: 1. .Adults aged ≥18 years with type 1 or type 2 diabetes mellitus, diagnosed according to WHO criteria. 2. .Presence of a chronic diabetic foot ulcer located below the ankle, classified as Wagner grade 2-3, with a post-debridement area of 5-80 cm². 3. .Target ulcer present for ≥4 weeks and unhealed despite ≥4 weeks of standard wound care prior to randomization. 4. .HbA1c \<12%, measured at screening or within 3 months prior to randomization. 5. .Any revascularization of the affected limb completed ≥4 weeks before randomization. 6. .Ability to provide written informed consent and comply with all study procedures and follow-up requirements. Exclusion Criteria: 1. .Active infection of the target ulcer requiring systemic antibiotics, or presence of non-removable necrosis, purulence, or sinus tracts. 2. .Significant peripheral arterial disease, defined as ABI \<0.7 or \>1.3. 3. .End-stage renal disease or eGFR \<20 mL/min/1.73 m². 4. .Active malignancy, uncontrolled autoimmune disease, or current use of systemic immunosuppressive therapy. 5. .Hematologic disorders that may impair wound healing. 6. .HIV infection or active hepatitis. 7. .Revascularization of the affected limb planned or performed within 4 weeks prior to randomization. 8. .Participation in another interventional clinical trial within 3 months prior to randomization. 9. .Pregnancy, lactation, or intention to become pregnant during the study period. 10. .Any condition that, in the investigator's judgment, could impair informed consent, protocol compliance, patient safety, or data reliability.