COOL-AMI EU Case Series Clinical Study

Inclusion Criteria: * The patient is 18 years of age. * The patient must have symptoms consistent with AMI * MI with ST-segment elevation * The patient is eligible for PCI. * The expected timing of the treatment pathway for the patient will allow for at least 10 minutes of cooling with the IVTM System prior to PCI. * The patient or patient legal representative is willing to provide written, informed consent to participate in this clinical study. Exclusion Criteria: * The patient has had a previous myocardial infarction * The patient is experiencing cardiogenic shock * The patient is experiencing acute pulmonary edema. * The patient is presenting with cardiac arrest. * The patient is presenting with Killip risk stratification class II through IV. * The patient is presenting with Atrial Fibrillation. * The patient has a history of a prior large myocardial infarct or an infarct in the same segment that is currently affected. * The patient requires an immediate surgical or procedural intervention other than PCI * The patient has an aortic dissection. * The patient has hepatic failure. * The patient has end stage kidney disease. * The patient is febrile * Known chronic Congestive Heart Failure (CHF). * Known previous CABG. * Known recent stroke * Cardio-pulmonary decompensation that has occurred en route to the hospital * Contraindications to hypothermia * The patient has a known hypersensitivity or contraindication to aspirin, heparin, or sensitivity to contrast media, which cannot be adequately pre-medicated. * The patient has a known history of coagulopathy * The patient is known to be pregnant * The patient has a known hypersensitivity to antishivering medications. * Patient has a known history of severe hepatic or renal impairment. * The patient has an Inferior Vena Cava filter in place (IVC). * The patient has a life expectancy of less than 1 year * The patient has a known, unresolved history of drug use * The patient is currently enrolled another investigational drug or device trial