Association of Periostin Levels and Chronic Sinusitis

N/AWithdrawnNCT02071667

University of Virginia

Overview

The purpose of this study is to see if a protein in blood, called periostin, can determine if patients have chronic sinusitis. This protein is in everyone's body, but the level of the protein may indicate certain conditions such as chronic sinusitis. The investigators are interested in testing levels of periostin to see if they are higher or lower than patients without chronic sinusitis, just as periostin is higher in patients with asthma. All patients enrolled in this study will have chronic sinusitis without asthma.

Study Type

OBSERVATIONAL

Conditions

Sinusitis Nasal Polyps

Interventions

Blood drawOTHER

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with sinus disease which requires surgical intervention * Ability to understand and give informed consent Exclusion Criteria: * Previous diagnosis of asthma * Positive methacholine challenge at screening * Diagnosis of cystic fibrosis * Concomitant use of systemic corticosteroids (except for those prescribed as part of standard pre-surgical treatment)

Locations (1)

University of Virginia

Charlottesville, Virginia, United States

Outcomes

Primary Outcomes

Difference in circulating serum periostin levels pre and post sinus surgery

Serum collected prior to and following sinus surgery will be analyzed for concentrations of the protein periostin.

Time frame: 10-15 weeks

Data from ClinicalTrials.gov

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