Imaging Study of Neurovascular Coupling in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL)

N/ACompletedNCT02071784

Institut National de la Santé Et de la Recherche Médicale, France60 enrolled

Overview

The aim of this study is to investigate using fMRI methods, EEG and dedicated mathematical models, the potential alterations of neurovascular coupling in CADASIL.

Comparison study of parameters derived from mathematical models of neurovascular coupling and obtained using fMRI (Bold signal, ASL and EEG).

Study Type

OBSERVATIONAL

Enrollment

Conditions

CADASIL

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * CADASIL group: typical NOTCH3 mutation, age less than 60 years, rankin score at 0-1, active social insurance Exclusion Criteria: * MRI contra-indications and use of any treatment known to interfere with neurovascular coupling, pregnancy, lack of informed consent

Locations (1)

CENIR, Hopital Pitié Salpetriere

Paris, France

Outcomes

Primary Outcomes

model-derived parameters of neurovascular coupling

Time frame: one time point

Data from ClinicalTrials.gov

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