The aim of this study is using intranasal dexmedetomidine versus intranasal midazolam-ketamine combination for premedication and preventing the oculocardiac reflex of pediatric patients undergoing strabismus surgery.
Preanesthetic medication in pediatrics is very helpful in relieving anxiety, fear and psychological trauma due to maternal deprivation. Midazolam and ketamine are commonly used for this purpose. Dexmedetomidine is an alpha 2 -agonist with a more selective action on the alpha 2 adrenoreceptor when administered via the nasal mucosa bioavailability of dexmedetomidine is too high. Intranasal route is an effective way to administer premedication and sedation to children. The oculocardiac reflex is a major complication of pediatric strabismus surgery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
60
via intranasal route 1 mcg/kg
via intranasal route 7,5 mg/kg ketamine and 0,1 mg/kg midazolam
Erciyes university hospital
Kayseri, Turkey (Türkiye)
the efficacy of premedication on ramsey sedation score
after drug administration ramsey sedation scale is evaluate every 5 min.
Time frame: 30 min after premedication
the effects of premedication on oculocardiac reflex
the heart rate drops the 20% of the resting rate
Time frame: during the surgery
mask acceptance scale
The subject's ability to accept the anesthesia mask is measured using the mask acceptance scale.
Time frame: 30 min after sedation
the parenteral separation anxiety scale
The response to the child parent separation is assessed and graded according to a 4 point scale at 30 min.
Time frame: 30 min after sedation
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