Radiolabeled Glass Beads in Treating Patients With Liver Cancer That Cannot be Removed by Surgery

Inclusion Criteria: * Diagnosis of intrahepatic malignancy including but not limited to HCC; the histopathology confirmation criterion may be waived in patients with a radiographically identifiable liver mass, known laboratory or clinical risk factors for cancer or elevated tumor markers such as alpha-fetoprotein (AFP) and clinical findings * Eastern Cooperative Oncology Group (ECOG) performance status score 0 - 2 * Life expectancy \>= 3 months * \> 4 weeks since prior radiation, surgery or chemotherapy * Able to comprehend and provide written informed consent in accordance with institutional and federal guidelines * Ineligible for surgical resection Exclusion Criteria: * Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) \> 5 times upper limit of normal (UNL) * Serum bilirubin \> 2.0 mg/dl (unless segmental infusion is planned) * Any contraindications to angiography and hepatic artery catheterization such as: * History of severe allergy or intolerance to any contrast media, narcotics, sedatives, or atropine that cannot be corrected or premedicated * Bleeding diathesis, not correctable by usual forms of therapy * Severe peripheral vascular disease that would preclude catheterization * Evidence of potential delivery of greater than 16.5 mCi (30 Gy absorbed dose) of radiation to the lungs in a single treatment * Evidence of pulmonary insufficiency * Evidence of any detectable technetium-99m macroaggregated serum albumin (Tc-99m MAA) flow to the stomach or duodenum, not correctable by using established angiographic techniques to stop or mitigate such flow * Significant extrahepatic disease representing an imminent life-threatening outcome * Active uncontrolled infection * Significant underlying medical or psychiatric illness * Co-morbid disease of condition that would preclude safe delivery of TheraSphere treatment or, in the judgment of the physician, place the patient at undue risk * Pregnancy