The MASS COMM Post-Randomization Phase Cohort Study

Inclusion Criteria: Candidates for this study must meet ALL of the following criteria: * Subject is at least 18 years old. * Subject requires single- or multi-vessel percutaneous coronary intervention (PCI) of de novo or restenotic target lesion (including in-stent restenotic lesions). N.B. staged procedure will not be considered to meet the endpoint component of repeat revascularization if either of the following pre-catheterization procedure qualifying clinical laboratory values are met: * eGFR is less than 60 ml/min or * creatinine is greater than 1.5 mg/dl * Subject's lesion(s) is (are) amenable to stent treatment with currently available FDA-approved bare metal or drug eluting stents. * Subject is an acceptable candidate for non-emergency, urgent or emergency CABG. * Subject has clinical evidence of ischemic heart disease in terms of a positive functional study, or documented symptoms. * Documented stable angina pectoris \[Canadian Cardiovascular Society Classification (CCS) 1, 2, 3, or 4\], unstable angina pectoris with documented ischemia (Braunwald Class IB-C, IIB-C, or IIIB-C), non-ST segment elevation myocardial infarction, or documented silent ischemia. * Subject and the treating physician agree that the subject will comply with all follow-up evaluations. * Subject has been informed of the nature and purpose of the study and agrees to its provisions and has provided written informed consent as approved by the Institutional Review Board/Ethics Committee of the respective clinical site. Angiographic Inclusion Criteria * The target lesion(s) is (are) de novo or restenotic (including in-stent restenotic) native coronary artery lesion(s) with greater or equal to 50 and less than 100% stenosis (visual estimate), or the target lesion is an acute (less than 1 month) total occlusion as evidenced by clinical symptoms. * If Fractional Flow Reserve (FFR) is measured, target lesion(s) has (have) evidence of a hemodynamically significant stenosis determined by FFR measurement (FFR less than or equal to 0.8). * Target lesions(s) is (are) located in an infarct (if not treated with primary PCI) or non-infarct-related artery with a 70% or greater stenosis (by visual estimate) greater than 72 hours following the STEMI. Lesions treated with PCI greater than 72 hours following STEMI would be subject to the same protocol inclusion/exclusion criteria listed above and below with the exception that a target lesion of 70% or greater stenosis may be treated with or without symptoms or abnormal stress test). Exclusion Criteria: Subjects will be excluded from participation in the Cohort Study (and non-emergency PCI may not be performed in these patients at the non-SOS site) if ANY of the following conditions apply: * The patient is pregnant or breastfeeding. * Evidence of ST segment elevation myocardial infarction within 72 hours of the intended treatment on infarct related or non-infarct related artery. * Cardiogenic shock on presentation or during current hospitalization. * Left ventricular ejection fraction less than 20%. * Known allergies to: aspirin, clopidogrel (Plavix), prasugrel (Effient), and ticlopidine (Ticlid), heparin, bivalirudin, stainless steel, or contrast agent (which cannot be adequately premedicated). * A platelet count less than 75,000 cells/mm3 or greater than 700,000 cells/mm3 or a WBC less than 3,000 cells/mm3. * Acute or chronic renal dysfunction (creatinine less than 2.5 mg/dl or less than 150µmol/L). * Subject is currently participating in an investigational drug or device study that has not completed the primary endpoint or that clinically interferes with the current study endpoints. (Note: Trials requiring extended follow-up for products that were investigational, but have since become commercially available, are not considered investigational trials). * Prior participation in the MASS-COMM Trial, unless the patient has completed the 12-month follow-up for the Trial, and/or prior participation in the Cohort Study, unless the patient has completed the 30-day follow-up for the Cohort Study. * Within 30 days prior to the index Cohort Study procedure, the subject has undergone a previous coronary interventional procedure of any kind. Note: This exclusion criterion does not apply to post-STEMI patients. * Stroke or transient ischemic attack within the prior 3 months. * Active peptic ulcer or upper GI bleeding within the prior 3 months. * Subject has active sepsis. * Unprotected left main coronary artery disease (stenosis greater than 50%). * Subject has evidence of a hemodynamically insignificant stenosis determined by FFR measurement (FFR greater than 0.8). * In the investigator's opinion, subject has a co-morbid condition(s) that could limit the subject's ability to participate in the study or comply with follow-up requirements or impact the scientific integrity of the study. Angiographic Exclusion Criteria * Subject has normal or insignificant coronaries (i.e., coronary lesion(s) less than 50% stenosis). * Any target vessel has evidence of: 1. excessive thrombus (e.g., requires target vessel thrombectomy) 2. tortuosity (greater than 60 degree angle) that makes it unsuitable for proper stent delivery and deployment, 3. heavy calcification. * Any target lesion requires treatment with a device other than PTCA prior to stent placement (e.g. but not limited to, directional coronary atherectomy, excimer laser, rotational atherectomy, etc.). * Any lesion that is located in a saphenous vein graft, however, lesions located within the native vessel but accessed through the graft are eligible. * The target vessel is in a "last remaining" epicardial vessel (e.g., \>2 non-target epicardial vessels and the bypass grafts to these territories \[if present\] are totally occluded).