Voriconazole is a broad-spectrum antifungal agent. There is evidence for a relation between the efficacy and safety of voriconazole and voriconazole trough concentrations. There are several factors that could influence voriconazole concentrations. Inflammation could be one of these factors. In a retrospective study was observed that reduced metabolism of voriconazole was related to inflammation in patients with severe infections. Reduced metabolism of voriconazole resulted in high voriconazole levels and low N-oxide metabolite (inactive metabolite of voriconazole) levels. The purpose of this study is to determine an algorithm to guide dosing of voriconazole during severe inflammation and to develop a multiple linear regression model to describe the contribution of CRP concentrations to the variability in voriconazole levels and metabolic ratio.
Study Type
OBSERVATIONAL
Enrollment
36
University Medical Center Groningen
Groningen, Netherlands
Plamsa concentration of voriconazole and voriconazole N-oxide in patients during a severe inflammation
Plasma concentrations of voriconazole and voriconazole N-oxide will be determined using a validated method involving LC-MS/MS
Time frame: Up to 1 month
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