The Effect of Ingesting or Rinsing Sucrose and Sucralose on Self-control, Cognitive Performance, and Blood Glucose

N/ACompletedNCT02075333

University of Leeds40 enrolled

Overview

The purpose of this study is to examine the effects of ingesting or mouth rinsing a sucrose (carbohydrate) versus a sucralose (carbohydrate-free) drink on self control, cognitive performance, and blood glucose level.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Self-control Cognitive Performance Blood Glucose Response

Interventions

Ingestion of solutionDIETARY_SUPPLEMENT

Participants will ingest the solution

Rinising of solutionDIETARY_SUPPLEMENT

Participants rinse the solution in the oral cavity

Eligibility

Sex: ALLMin age: 50 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * BMI 18 - 29 kg/m2 Exclusion Criteria: * Dementia * Depression * Type 2 diabetes * Phenylketonuria * Intake of medication known to affect glucose metabolism * Fasting blood glucose \> 7.8 mmol/L

Locations (1)

Human Appetite Research Unit (University of Leeds)

Leeds, United Kingdom

Outcomes

Primary Outcomes

Capillary blood glucose change from baseline following rinsing or ingesting sucrose or sucralose solutions

Change from baseline in capillary blood glucose (assessed by lancet fingerprick and YSI blood glucose analyser)

Time frame: - 30, -15, - 5, + 5, + 10, + 20, + 30, + 40 minutes relative to rinsing or ingestion of sucrose or sucralose solutions (each separated by 7 days in crossover manner)

Secondary Outcomes

Visual verbal learning and memory performance following self-control depletion

Visual verbal learning performance will be assessed by the Visual Verbal Learning Test (Rey, 1964) following a self-control depletion task and ingestion or rinsing of a sucrose or sucralose solution

Time frame: + 35 minutes post ingestion or rinsing of sucrose or sucralose solutions (each separated by 7 days in crossover manner)

Attention switching performance following self-control depletion

Attention switching performance will be assessed by a switch task (Rogers and Monsell, 1995) following a self-control depletion task and ingestion or rinsing of a sucrose or sucralose solution

Time frame: + 20 minutes post ingestion or rinsing of sucrose or sucralose solutions (each separated by 7 days in crossover manner)

Continuous blood glucose change from baseline following rinsing or ingesting sucrose or sucralose solutions

A subgroup of 10 participants recruited into the study will be fitted with a continuous glucose monitoring device (CGMS, iPRO) the day preceding each of the test days to measure continuous interstitial blood glucose levels

Time frame: 24 hours preceding and during ingestion or rinsing of sucrose or sucralose solutions (each separated by 7 days in a crossover manner)

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.