Immune Characterization of Subcutaneous Adipose Tissue

N/ACompletedNCT02076087

Washington University School of Medicine19 enrolled

Overview

The overall goal of this proposal is to characterize the immune cell profile of subcutaneous abdominal adipose tissue in lean, overweight, obese and lipedema adults, and to evaluate potential associations between different adipose tissue immune cell types and metabolic profile.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Determine Immune Cell Types in Subcutaneous Adipose Tissue

Interventions

Liposuction/lipectomyPROCEDURE

Subcutaneous adipose tissue will be obtained from liposuction/lipectomy to determine the types of immune cells

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Women of all races and ethnicity * Age between 18 and 65 years * Body Mass Index (BMI) ≥ 18.5 kg/m² * Weight stable (+/- 3% during the last 2 months before enrollment) * Women already scheduled for above mentioned procedures Exclusion Criteria: * Diabetes Mellitus * Recent (\<5 years) history of cancer (except in situ ductal breast carcinoma) * Chemotherapy and/or radiation therapy within 4 months before enrollment * Immune system diseases (i.e., autoimmune disorders, acquired immunodeficiency syndrome) * Pregnant or breastfeeding * Take any medication that might affect immune function * Severe organ dysfunction * BMI \<18.5 kg/m² or size of each breast is \>600 grams, if scheduled for bilateral breast reconstruction

Locations (1)

Washington University School of Medicine

St Louis, Missouri, United States

Outcomes

Primary Outcomes

Determine the types of immune cells and the relative prevalence of each type and sub-type, in subcutaneous adipose tissue of normal weight, overweight, obese and lipedema adults.

Time frame: intraoperative

Secondary Outcomes

Determine the relationships among specific types and subtypes of immune cells, adiposity and cardiometabolic risk.

Time frame: Baseline

Data from ClinicalTrials.gov

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