A Phase 1 TH-302 Mass Balance Trial

Inclusion Criteria: * Male subject with pathologically or cytologically confirmed solid tumor which is locally advanced or metastatic, and either refractory to the standard therapy or for which no effective standard therapy is available * Subject has measurable and evaluable disease as RECIST version 1.1 * Age greater than or equal to (\>=) 18 years and less than or equal to (=\<) 70 years * Body mass index (BMI) \>= 19 and =\< 33 kilogram per square meter (kg/m\^2), body weight greater than (\>) 50 kilogram (kg) * Eastern cooperative oncology group (ECOG) performance status of 0 to 1 * Life expectancy of at least 3 months * At least 4 weeks from previous cytotoxic chemotherapy or radiation therapy and at least 5 half-lives or 6 weeks, whichever is longer, after targeted or biologic therapy * Acceptable renal function, liver function and hematologic status as defined in the protocol * Other protocol-defined inclusion criteria could apply Exclusion Criteria: * New York Heart Association (NYHA) Class 3 or 4 congestive heart disease, myocardial infarction within 6 months, unstable arrhythmia, symptomatic ischemic heart disease or symptomatic peripheral arterial vascular disease * Severe chronic obstructive or other pulmonary disease with hypoxemia as defined in the protocol * Major surgery, other than diagnostic surgery, =\< 28 days prior to Day 1. Subject must have completely recovered from surgery * Primary brain tumors or clinical evidence of active brain metastasis as defined in the protocol * Treatment with strong inhibitors and/or inducers of drug metabolic enzymes or drug transporter as defined in the protocol * Participation in a drug trial within 30 days prior to start of trial medication. Participation in a trial involving administration of 14C-labeled compound(s) within last 6 months prior to start of study drug * Inability to understand the protocol requirements, instructions and trial-related restrictions, the nature, scope, and possible consequences of the trial * Legal incapacity or limited legal capacity * Other protocol-defined exclusion criteria could apply