Deep Brain Stimulation of the Anterior Nucleus of the Thalamus in Epilepsy

Inclusion Criteria: * Patient with focal or multifocal epilepsy with or without secondary generalized seizure inoperable at the time of inclusion * Failure of pharmacological therapies (pharmacoresistant epilepsy) for over 4 years (persistent seizures despite at least two anti-epileptic treatments used at the optimal dose for at least 2 years) * Failure of vagus nerve stimulation, defined as the persistence of crises considered debilitating after 2 years of VNS's treatment * VNS failure in a patient treated with VNS, for less than 2 years. with stop early due to the worsening crisis * Intelligence quotient above 55 * Have the written consent of the legal representative for patients under guardianship and minors * Affiliation to the french social security system or equivalent * People who signed the consent form * Seizure frequency at least 4 crisis / month on average for at least 3 months, about 12 crisis in 3 months objectified by the neurologist during visit pre-inclusion, and confirmed by the neurologist after 3 months of Baseline during the inclusion visit Exclusion Criteria: * Patient with a generalized epilepsy Immediately * Patient with a simple partial seizures (subjective manifestations only) * Patient with a cons-indication for MRI, a serious intercurrent disease, a progressive brain tumor * Patient with a suicide risk of in the six months preceding the inclusion visit (score ≥ 2 on item 10 of the Montgomery-Asberg Depression Rating Scale) * Patient a surgical or anesthetic cons-indication * Patient with anticoagulant or antiplatelet treatment in the long term * Woman of childbearing potential without effective contraception, or pregnant or lactating * People hospitalized without consent * People deprived of freedom * Patient currently participating in another clinical research, or who participated in a clinical study in the month preceding the pre-inclusion visit (except for any non-interventional research)