Effects of Physical Training on Adipose Tissue Metabolism and Insulin Sensitivity in the Menopausal Transition Phase

N/ACompletedNCT02076932

University of Copenhagen43 enrolled

Overview

The purpose of this study is to determine if physical exercise reduces the adverse changes in adipose tissue metabolism and insulin sensitivity that occurs in women during the menopausal transition.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Menopause Insulin Resistance Body Composition, Beneficial

Interventions

SpinningBEHAVIORAL

After the baseline studies, the women will perform Spinning three times a week. Two of the sessions are performed on our location by trained instructors and the third training is self-training in a local fitness center where we provide free membership. All trainings are heart rate monitored.

Eligibility

Sex: FEMALEMin age: 45 YearsMax age: 57 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Premenopausal OR Postmenopausal (45-57 years) * No chronical Diseases * BMI \> 18,5 and \< 30 * Sedentary (no regular physical activity the last 2 years) * Either regular bleeding (premenopausal) OR no menstruation for at least 2 years (postmenopausal) * Plasma measurements: Premenopausal: estradiol \> 0.20nmol/l, Follicle Stimulating Hormone \< 22 IU/l and progesterone \> 2.5 nmol/l Postmenopausal: estradiol \< 0.20nmol/l, Follicle Stimulating Hormone \> 22 IU/l and progesterone from 0.3-2.5 nmol/l Exclusion Criteria: * Smoking * Excessive alcohol intake * Regular medication including hormone replacement treatment

Locations (1)

Department og Biomedical Sciences

Copenhagen N, Denmark